Abstract
OBJECTIVE: Trauma survivors are more likely than others to use cannabis, and post-traumatic stress disorder (PTSD) commonly co-occurs with cannabis use disorder (CUD). Automatic memory associations between trauma reminders and cannabis use have been suggested as contributing mechanisms. These associations can be studied experimentally by manipulating trauma cue exposure in a cue-reactivity paradigm (CRP) and examining effects on the accessibility of cannabis information in memory in trauma survivors with and without PTSD. METHOD: Cannabis users with trauma histories (N = 202) completed a PTSD measure (PTSD Checklist-5) and were randomized to a trauma or neutral expressive writing task as an online CRP. Next, participants completed a cue-behavior word association task, which involved presentation of a series of ambiguous cue words to which participants provided the first word that came to mind. Some of these ambiguous cues pertained to cannabis (e.g., weed, pot) and some to other substances (e.g., blow, shot). This task was scored by two independent raters. Linear regression models tested the hypothesized main and interactive effects of CRP condition (trauma, neutral) and PTSD group (probable PTSD, no PTSD) on the number of cannabis and other substance responses generated. RESULTS: Main effects of CRP condition were found for cannabis responses (b = 0.41, p = .048; trauma > neutral) but not other substance responses. Unexpectedly, no main effects or interactions of PTSD group were observed for either outcome. CONCLUSIONS: In cannabis users with trauma histories, writing about one's trauma specifically activates greater accessibility of cannabis-related information in memory, regardless of PTSD.