Abstract
Desmoplastic fibroma (DF) is an uncommon benign bone tumor that typically affects the facial bones, with cerebral cranium involvement being extremely rare. We report a unique case of DF in the parietal bone of a 28-year-old woman, notable for its rapid growth during pregnancy-a phenomenon not previously documented. The imaging features of this case also differ from all but one previously reported case. The patient underwent surgical removal, and histopathology confirmed the diagnosis of DF (collagenous fibroma). After 17 months of follow-up, no local recurrence was observed. We also provide a comprehensive review of 32 cases involving DF of the cerebral cranium, analyzing clinical features, imaging findings, treatment methods, and recurrence patterns. This case highlights the importance of considering DF in the differential diagnosis of cranial lesions, particularly in pregnant patients with rapid tumor growth. Complete surgical resection with a wide margin remains the recommended treatment to minimize recurrence risk.