Abstract
A 71-year-old female with a history of hypertension, diabetes, and dyslipidemia developed altered mental status, fever, headache, and vomiting. Subsequent evaluation revealed meningoencephalitis and ventriculitis due to Streptococcus oralis, which was found to be ceftriaxone-sensitive. The patient's condition improved with ceftriaxone treatment, leading to complete recovery. This case underscores the significance of including Streptococcus oralis in the differential diagnosis of meningitis or encephalitis.