Abstract
Polycystic ovary syndrome (PCOS) is a multiple endocrine disorder associated with significant reproductive and metabolic manifestations. A genetic variation at the level of aromatase enzyme gene (CYP19 gene) and/or androgen receptors with subsequent increased ovarian androgen was suggested in PCOS. Recently, researchers noted that 56% of the PCOS women had evidence of hypothyroidism and this report represents three case of PCOS with hypothyroidism and hyperprolactinemia (Abdelazim and Sakiyeva endocrinopathy associated with PCOS) to highlight the hypothyroidism and hyperprolactinemia as a common endocrinopathy associated with PCOS. PCOS women should be screened for the endocrinopathy associated with PCOS especially the hypothyroidism and hyperprolactinemia because the undiagnosed endocrinopathy aggravates the PCOS symptoms.