Role of alphavbeta6 integrin in acute biliary fibrosis
αvβ6整合素在急性胆道纤维化中的作用
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作者:Bruce Wang, Brian M Dolinski, Noriko Kikuchi, Diane R Leone, Marion G Peters, Paul H Weinreb, Shelia M Violette, D Montgomery Bissell
| 期刊: | Hepatology | 影响因子: | 12.900 |
| 时间: | 2007 | 起止号: | 2007 Nov;46(5):1404-12. |
| doi: | 10.1002/hep.21849 | 种属: | Mouse |
| 靶点: | Ly-6G | |
Conclusion
Cholangiocytes respond to acute bile duct obstruction with markedly increased expression of alphavbeta6 integrin, which is closely linked to periductal fibrogenesis. The findings provide a rationale for the use of inhibitors of alphavbeta6 integrin or TGFbeta for down-regulating fibrosis in the setting of acute or ongoing biliary injury.
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