Abstract
RATIONALE: TFEB-associated renal cell carcinoma is very rare and belongs to the microphthalmia - associated transcription family translocation renal cell carcinoma. PATIENT CONCERNS: Hospitalized for fever, a 29-year-old male patient had a left kidney lesion without any additional discomfort. DIAGNOSES: Histopathological and immunohistochemical results were corresponding with TFEB renall cell carcinoma features. INTERVENTIONS: Surgical resection of the tumor was performed. OUTCOMES: After 8 months of follow-up, no tumor recurrence was observed. LESSONS: TFEB-associated renal cell carcinoma is rare. The diagnosis is explicit. However, the optimal treatment needs to be further explored.