Abstract
INTRODUCTION: We describe a rare case of a 54-year-old male diagnosed with both ulcerative colitis (UC) and hepatitis C virus (HCV), posing clinical challenges. PATIENT CONCERNS: The patient showed worsened UC symptoms, leading to further evaluations. DIAGNOSIS: Dual diagnosis of UC and HCV was confirmed through endoscopy and serological tests, ruling out other hepatic causes. Interventions: Treatment involved methylprednisolone for UC and sofosbuvir/velpatasvir for HCV, with attention to drug interactions. OUTCOMES: Significant improvement was observed in both UC symptoms and HCV viral load post-treatment. CONCLUSION: This case underscores the need for nuanced treatment in managing concurrent UC and HCV, considering potential drug interactions and disease impacts.