Abstract
INTRODUCTION AND IMPORTANCE: Primary malignant pericardial mesothelioma is an extremely rare disease with a poor prognosis. Currently, there are no specific guidelines for diagnosis and treatment in Vietnam and international countries for this disease, so treatment experiences from previous clinical cases are very important in the management of this disease. CASE PRESENTATION: The research team reports a clinical case diagnosed and treated with a combination of surgery and chemotherapy using the Pemetrexed + Carboplatin regimen at the Oncology Center. The patient has survived for an additional 17 months up to the current time. CLINICAL DISCUSSION: This is an exceptionally rare incident. He survived for a duration of 17 months, which is almost three times longer than the average survival time observed in other documented cases. Additional reports on cases with pericardial mesothelioma are necessary to have a comprehensive understanding of its nature, enabling early identification and appropriate treatment. CONCLUSION: The patient underwent surgical intervention and received chemotherapy as part of their treatment. The research team emphasizes the importance of a multidisciplinary approach in diagnosing and treating primary malignant pericardial mesothelioma.