Abstract
Secretory breast carcinoma (SBC) is a rare breast cancer subtype, histologically, defined by abundant eosinophilic secretions with a triple-negative staining on immunohistochemistry. The diagnosis is made histologically and often requires complementary methods such as immunohistochemical studies and fluorescence in situ hybridization (FISH). Surgery, whether conservative or radical, is the preferred treatment. The prognosis remains good. We report a case of a 46-year-old woman who presented with a right breast upper quadrant lump. She underwent a mastectomy with axillary curage. The pathological result was in favor of a breast secretory carcinoma. The lack of any poor prognostic factors allowed the patient to be placed on close follow-up with a good outcome and no recurrence or metastasis in the last two years.