Abstract
Salivary exosomes are extracellular vesicles of 30-150 nm in diameter that exist in saliva and play an important role in substance exchange and signal transduction between cells, delivering the lipids, proteins and nucleic acids they carry to the recipient cells and regulating the physiological and pathological processes of the recipient cells. miRNA, as an important "cargo" in exosomes, is transported to the recipient cells and regulates the signaling pathways of the recipient cells, thus playing a regulatory role in disease progression. The miRNAs are transported to the recipient cells and regulate the signaling pathways of the recipient cells, thus playing a regulatory role in the progression of diseases. With the development of technological tools this year, numerous studies have revealed the important role of salivary exosomal miRNAs in the development of head and neck squamous carcinoma and the role of salivary exosomal miRNAs in the diagnosis and treatment of head and neck squamous carcinoma. This paper reviews the occurrence, treatment and prognosis of salivary exosomal miRNA in head and neck squamous carcinoma, and discusses the potential prospects and importance of salivary exosomal miRNA as a biomarker in the diagnosis of head and neck squamous carcinoma.