Abstract
Michael P. Sheetz made immense contributions to our understanding of motor proteins, membrane biology, cytoskeleton and mechanobiology over his ~50-year career. He started his independent career at the University of Connecticut, after which he moved to Washington University in St. Louis and then to Duke University, where he led the Department of Cell Biology for 10 years. He then moved to Columbia University, where he established a research group focused on mechanobiology, and then founded and led the Mechanobiology Institute at the National University of Singapore for 10 years. He ended his career at the University of Texas Health Center in Galveston, TX, USA. He trained a generation of leading interdisciplinary cell and mechanobiologists whose independent contributions continue to enhance his legacy.