Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury

Toll 样受体 9 抑制可保护肝脏免受缺血再灌注损伤

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作者:Zubin M Bamboat, Vinod P Balachandran, Lee M Ocuin, Hebroon Obaid, George Plitas, Ronald P DeMatteo

Conclusion

TLR9 serves as an endogenous sensor of tissue necrosis that exacerbates the innate immune response during liver I/R. Combined blockade of TLR9 and HMGB1 represents a clinically relevant, novel approach to limiting I/R injury.

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