Abstract
Cortical neurons are heterogeneous in their functional properties. This heterogeneity is fundamental for the processing of different features of sensory information. However, functional diversity within a local group of neurons is poorly understood. Here, we demonstrate that neighboring cortical neurons in layer 5 but not those of layer 4 of the rat anterior auditory field (AAF) exhibited a surprisingly high level of diversity in tonal receptive fields. In vivo whole-cell voltage-clamp recordings revealed that the diversity of frequency representation was due to a spectral mismatch between synaptic excitation and inhibition to varying degrees. The spectral distribution of excitation was skewed at different levels, whereas inhibition was homogeneous and non-skewed, similar to the summed spiking activity of local neuronal ensembles, which further enhanced diversity. Our results indicate that AAF in the auditory cortex is involved in processing auditory information in a highly refined manner that is important for complex pattern recognition.