Abstract
Headache is a common neurologic manifestation of COVID-19 that usually has benign features and has been considered as a good prognostic factor. However, occasionally such symptoms could be due to a serious cause such as cerebral venous sinus thrombosis or meningitis/encephalitis. The activation of the trigeminovascular system has been proposed as an underlying mechanism of headaches that are associated with disease. The ICHD3 criteria can be used to classify headaches as acute related to systemic viral infection, viral meningitis, encephalitis, or other noninflammatory intracranial diseases, as secondary cough headaches, headaches attributed to hypoxia and/or hypercapnia, headaches due to cranial or cervical vascular disorders, and headaches attributed to increased cerebrospinal fluid pressure. Apart from headaches caused by infection with COVID-19, an increasing number of patients, with or without a previous history of headache, have experienced them because of lifestyle changes during the COVID-19 pandemic.