Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection

肝细胞衍生的外泌体在丙型肝炎病毒感染期间促进 T 滤泡调节细胞扩增

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作者:Dustin A Cobb, Ok-Kyung Kim, Lucy Golden-Mason, Hugo R Rosen, Young S Hahn

Conclusion

These results show that liver-derived exosomes play a pivotal role in the accumulation of Tfr cells, likely leading to suppression of Tfh responses in HCV-infected patients. Our study identifies a novel pathway in which HCV infection in hepatocytes exacerbates Tfr cell responses to subvert antiviral immunity. (Hepatology 2018;67:71-85).

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