Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection
肝细胞 NAD(P)H 氧化酶是丙型肝炎病毒感染期间活性氧的内源性来源
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作者:Nabora Soledad Reyes de Mochel, Scott Seronello, Shelley Hsiuying Wang, Chieri Ito, Jasper Xi Zheng, T Jake Liang, J David Lambeth, Jinah Choi
| 期刊: | Hepatology | 影响因子: | 12.900 |
| 时间: | 2010 | 起止号: | 2010 Jul;52(1):47-59. |
| doi: | 10.1002/hep.23671 | 研究方向: | 免疫、细胞生物学 |
| 疾病类型: | 肝炎 | 细胞类型: | 其它细胞 |
Conclusion
HCV induced a persistent elevation of Nox1 and Nox4 and increased nuclear localization of Nox4 in hepatocytes in vitro and in the human liver. Hepatocyte Nox proteins are likely to act as a persistent, endogenous source of ROS during HCV-induced pathogenesis.
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