Direct Conversion of Cord Blood CD34+ Cells Into Neural Stem Cells by OCT4

利用 OCT4 将脐带血 CD34+ 细胞直接转化为神经干细胞

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作者:Wenbin Liao, Nick Huang, Jingxia Yu, Alexander Jares, Jianchang Yang, Gary Zieve, Cecilia Avila, Xun Jiang, Xiao-Bing Zhang, Yupo Ma

Significance

This study describes a novel method to generate expandable induced neural stem cells from human cord blood cells in a feeder-free system by a single factor, OCT4. The data are promising for future applications that require the generation of large amounts of autologous neural stem cells in disease modeling and regenerative medicine.

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