Abstract
Neurons in primary visual cortex (area V1) adapt in varying degrees to the average contrast of the environment, suggesting that the representation of visual stimuli may interact with the state of cortical gain control in complex ways. To investigate this possibility, we measured and analyzed the responses of neural populations in mouse V1 to visual stimuli as a function of contrast in different environments, each characterized by a unique distribution of contrast values. Our findings reveal that, for a fixed stimulus, the population response can be described by a vector function r(g(e)c), where the gain g(e) is a decreasing function of the mean contrast of the environment. Thus, gain control can be viewed as a reparameterization of a population response curve, which is invariant across environments. Different stimuli are mapped to distinct curves, all originating from a common origin, corresponding to a zero-contrast response. Altogether, our findings provide a straightforward, geometric interpretation of contrast gain control at the population level and show that changes in gain are well matched among members of a population.NEW & NOTEWORTHY The authors study the responses of neural populations in mouse primary visual cortex as a function of stimulus contrast. Measurements are performed in different "environments," each characterized by a different distribution of contrast values. They find that responses across environments can be viewed as a reparameterization of a single contrast-response curve, offering a simple, geometric account of contrast gain control in neural populations.