Abstract
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this systematic review was to assess the efficacy (OS, PFS, EFS, RR), safety (rate of cytopenias, transfusions, fever, antibiotic use, infusion reactions, secondary malignancies) and QOL of standard chemotherapy regimens (CHOP and other chemotherapy regimens) with and without rituximab for aggressive B‐cell lymphoma in adult patients.