Abstract
BACKGROUND: Substance use disorder (SUD) remains a significant public health issue, with a high relapse rate even after detoxification treatment. Family dysfunction has been identified as a closely related factor contributing to relapse in individuals with SUD. The objective of this study was to investigate the mediating role of family climate in the relapse tendency among patients with SUD. METHODS: The study employed a case-control design using the survey method. A total of 103 patients from the addiction unit daycare at Mansoura University Hospital were divided into 2 groups: the relapsed group and the abstinent group. The Relapse Tendency Questionnaire, the Family Climate Scale, and a structured interview were administered to collect sociodemographic data. FINDINGS: The results revealed significant differences between the study groups in terms of sociodemographic risk factors, including marital status (P≤0.001), employment (P=0.043), and economic status (P=0.028). Additionally, a significant difference was observed between the study groups in terms of the Family Climate Scale (P=0.038). Female participants reported that familial factors had a greater influence on their relapse compared to male participants (P=0.005). CONCLUSION: A statistically significant difference was found in the family climate subscale scores between the relapsed patients and the abstinent patients with SUD, confirming the influential role of family climate in the relapse process of SUD.