Abstract
BACKGROUND: Isolated parenchymal gastric metastasis of endometrial cancer without other recurrence sites is extremely rare. This report presents a case of isolated gastric metastasis from endometrioid carcinoma characterized by a giant ulcer, which was managed with radical resection. Additionally, we review the recently published literature regarding isolated gastric metastases originating from ovarian and endometrial cancers. CASE DESCRIPTION: A 60-year-old female was admitted with discomfort in the upper abdomen accompanied by melena and a 6-year history of ovarian and endometrial cancer. Gastroscopy revealed a giant ulcer located in the gastric body, and biopsy pathology indicated a reproductive system origin. Subsequent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) revealed a hypermetabolic lesion within the gastric wall on the lesser curvature [standardized uptake value (SUV): 23.23]. Final pathology following total gastrectomy confirmed the presence of an isolated gastric metastasis tumor originating from primary endometrial endometrioid carcinoma. The patient was discharged 11 days postsurgery and exhibited no signs of recurrence or metastasis during a 3-month postoperative follow-up. CONCLUSIONS: Early diagnosis and treatment are paramount for identifying metastatic gastric lesions. If surgery is feasible and safe, cytoreductive surgery followed by adjuvant chemotherapy represents an effective and widely endorsed treatment approach, significantly improving patient prognosis and enhancing long-term survival rates.