Abstract
While historically utilized as a topical anesthetic and active ingredient in a variety of tonics, beverages and cure-alls, cocaine is a commonly abused illicit substance. Cocaine use is associated with a variety of neurological and systemic complications. The present study describes the case of a 23-year-old female patient presenting with profound neurological and systemic complications of cocaine, including coma, leukoencephaloapthy, neurogenic stunned myocardium, transaminitis, acute kidney injury, rhabdomyolysis and mononeuropathy. The supportive management and subsequent outcomes of the patients are discussed in detail. The approach to coma is also discussed, including stabilization and supportive care, diagnostic considerations and management. Key considerations relating prognosticating disorders of consciousness are also highlighted.