Abstract
Lung cancer has a higher incidence and mortality rate than other cancers do. Sarcopenia significantly affects therapeutic outcomes and prognostic prospects in patients with lung cancer. Rapid identification and early intervention for sarcopenia are priorities. Current diagnostic guidelines have limitations, particularly for nonambulatory or critically ill patients, where ultrasonography has emerged as a practical alternative. This study aims to evaluate the utility of ultrasonography in assessing skeletal muscle health and sarcopenia severity in lung cancer patients. This study was a secondary analysis of our previous research and analyzed clinical and imaging data from 82 lung cancer surgery patients and 53 benign controls. All participants underwent grayscale ultrasonography and shear wave elastography (SWE) of the rectus femoris (RF), measuring RFthick, RFcsa, RFmgv, and CSmean. Based on muscle strength and physical function, patients were categorized into 3 groups: non-sarcopenic (Group I), sarcopenic (Group II), and severely sarcopenic (Group III). Lung cancer patients exhibited lower RFthick, RFcsa, and CSmean but higher RFmgv compared to benign controls, with significant differences in RFcsa, RFmgv, and CSmean among the groups (P < .05). Additionally, RFmgv and CSmean varied significantly among lung cancer patients with different sarcopenia severities (P < .05). Ultrasonography of the RF provides objective measures for assessing skeletal muscle health in patients with lung cancer and is vital for evaluating sarcopenia severity.