Abstract
Pilomatrixoma is a rare subcutaneous tumor originating from the cellular matrix of hair follicles. While it predominantly arises during the first two decades of life, its occurrence in elderly patients is exceedingly rare. We present the case of an 83-year-old woman with a recently growing, indurated nodule located on the right upper eyelid. Her medical history included left breast cancer treated with tumorectomy, radiotherapy, and chemotherapy, with remission since 2012. Given her advanced age and oncological history, differential diagnoses included malignant tumors, metastasis, or recurrence of breast cancer involving the head and neck region. Histopathological analysis confirmed the diagnosis of pilomatrixoma, which was completely excised with clear margins. The postoperative course was uneventful, and no recurrence was observed at one-month follow-up. This case highlights the importance of including pilomatrixoma in the differential diagnosis of head and neck lesions in elderly patients.