Abstract
PURPOSE: Although conventional multi-echo gradient-echo (GRE) sequences effectively quantify short and intermediate T(2)* in brain tissue, and general interest in cerebrospinal fluid (CSF) is growing due to its association with the glymphatic system, quantifying T(2)* in CSF remains underexplored. Accurate quantification of the slow-relaxing water pools requires imaging at long echo times, significantly increasing acquisition time. This study proposes a novel sequence capable of quantifying the entire range of T(2)* without prolonged acquisition time, mapping T(2)* in both CSF and brain tissue. METHODS: The proposed echo-shifted, multi-echo GRE (ES-mGRE) combines the conventional multi-echo GRE sequence with an echo-shifting technique. Additional gradients are introduced, producing echoes in the next sub-repetition time interval. RESULTS: ES-mGRE generates artifact-free images at both short and long echo times without extending acquisition time. Increasing the area of the additional gradients enhances diffusion sensitivity, allowing simultaneous quantification of T(2)* and D in CSF. The mean T(2)* of white matter and gray matter is 55.9 ms and 51.5 ms at 3 T, respectively. The mean T(2)* in the ventricles is 234.5 ms. The simultaneously quantified mean D value of 3.07 μm(2)/ms is closely aligned with the reference diffusivity. CONCLUSION: We demonstrate that the proposed ES-mGRE sequence can effectively quantify the T(2)* of both CSF and brain tissue while also providing simultaneous diffusion information.