Abstract
BACKGROUND: The left piriform cortex and amygdala (PC&A) tend to be slightly hyperintense relative to the right PC&A on T2-weighted fluid-attenuated inversion recovery (T2W-FLAIR) images in patients with probable Alzheimer's disease (pAD). This likely represents the antecedent and thus advanced degeneration of the left PC&A. PURPOSE: To investigate the relationship between left PC&A hyperintensities and cerebral cortical atrophy on magnetic resonance (MR) voxel-based morphometry in patients with pAD and discuss how this finding could relate to AD progression. MATERIAL AND METHODS: Patients with pAD (n = 47; age range = 68-93 years, mean = 80.8 ± 6.7 years; 14 men and 33 women) who underwent T2W-FLAIR imaging and MR morphometric study using a voxel-based specific regional analysis system for AD (VSRAD) were retrospectively examined. To measure signal intensity ratios of the left to right PC&A (L-PC&A/R-PC&A), regions of interest (ROIs) were set on the transaxial images in which both PC&As were most broadly depicted; the ROIs were defined as large as possible. Correlations between the L-PC&A/R-PC&A and medial temporal lobe cortical atrophy (MTLCA) as well as whole cerebral cortical atrophy (WCCA) on VSRAD were determined. Correlation between the L-PC&A/R-PC&A and age was also determined. RESULTS: The L-PC&A/R-PC&A correlated with both MTLCA (r = 0.375, p = .010, 95% confidence interval [CI] = 0.095-0.600) and WCCA (r = 0.576, p < .001, 95% CI = 0.343-0.742). The L-PC&A/R-PC&A did not correlate with age (r = 0.013, p = .932, 95% CI = -0.282-0.305). CONCLUSION: Left-sided dominance of PC&A degeneration appeared to accelerate with the progression of AD stages.