Abstract
Mucormycosis is an immunosuppression-related fungal infection. This pathogen usually manifests as an acute and rapidly progressive, deforming, and lethal disease, but chronic forms of zygomycosis occur rarely. Here we present a case of a 15-year-old female with ataxia-telangiectasia syndrome, reporting a six-month history of recurrent sinusitis and an atypical secondary skin infection characterized by ulcerated nodules and crusted plaques, unresponsive to multiple treatments. This case highlights the changing epidemiology of opportunistic infections, which were usually confined to specific immunosuppressive diseases but are recently presenting a shift towards their associated risk factors and comorbidities.