Abstract
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the most prevalent carcinoma of the head-and-neck region. Despite advanced tissue diagnosis, the survival period remains at 5 years. New molecular and cell markers are under investigation to improve survival rate. OBJECTIVE: The objective of this study was to assess angiogenic activity by analyzing CD105 microvascular density (MVD) count in different histologic grades of OSCC. SUBJECTS AND METHODS: Sixty samples are categorized into four groups. Immunohistochemical method with anti-CD105 was used for analyzing MVD. RESULTS: The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. A highly significant correlation is observed among different groups of OSCC samples. CONCLUSION: CD105 is a predictive marker for neoangiogenesis in OSCC.