Abstract
PURPOSE: To investigate the risk factors for hemorrhagic cystitis (HC) in children with severe beta-thalassemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: The clinical data of 152 children under the age of 15 who underwent allo-HSCT between January 2011 and December 2021 were retrospectively analyzed. The incidence of HC and related variables were evaluated using univariate analysis. Variables with statistical significance (P < 0.05) were included in a multivariable logistic regression model to identify independent risk factors for HC. RESULTS: Among the 152 children, 42 developed HC, with an incidence rate of 27.63%. The median onset time of HC was 25 days (IQR: 10-38.75 days). Univariate analysis indicated that older transplantation age, elevated pre-transplant serum ferritin levels, cytomegalovirus (CMV) infection, and prolonged neutrophil engraftment time were associated with HC occurrence (P < 0.05). Multivariable logistic regression further confirmed that older transplantation age (OR 1.236, 95% CI: 1.031-1.531, P = 0.033), elevated pre-transplant ferritin levels (OR 1.053, 95% CI: 1.028-1.086, P < 0.01), CMV infection (OR 11.522, 95% CI: 2.912-76.345, P = 0.002), and prolonged neutrophil engraftment time (OR 1.385, 95% CI: 1.109-1.793, P < 0.01) were independent risk factors for HC. CONCLUSION: Older transplantation age (>5.95 age years old), elevated pre-transplant serum ferritin levels, CMV infection, and delayed neutrophil engraftment are independent risk factors for HC in children with severe beta-thalassemia after allo-HSCT. Early identification and intervention for these risk factors are crucial in reducing the incidence of HC.