Abstract
Prurigo nodularis (PN) is a chronic inflammatory skin disorder marked by intense itching and firm, pruritic nodules, often linked to dermatologic, autoimmune, or systemic conditions, including malignancies such as hematologic cancers. We present two cases illustrating PN as a potential cutaneous manifestation of hematologic malignancies: a 48-year-old male with a history of psoriasis and persistent pruritus misdiagnosed as scabies, later found to have Hodgkin lymphoma, and an 86-year-old female with fatigue, anemia, and erythematous lesions diagnosed with Waldenström macroglobulinemia. These cases underscore the importance of recognizing PN as a symptom of underlying malignancy, enabling earlier diagnosis and treatment to improve outcomes.