Abstract
BACKGROUND: Thrombocytopenia is a common manifestation of antiphospholipid syndrome (APS). This study assesses the possible relationship between severe thrombocytopenia and adverse pregnancy outcomes (APOs) in obstetric APS (OAPS) patients. METHODS: An observational, cohort study was conducted at Peking University People's Hospital, Beijing, China. The demographic, clinical, immunologic, and pregnancy outcomes of the OAPS patients were collected. Univariate and multivariate logistic regression analyses were applied to assess the association between APOs and severe thrombocytopenia (< 30 × 10(9)/L). The threshold effect was explored using two piecewise linear regression models by the smoothing plot. RESULTS: A total of 176 OAPS participants were included in the analysis, with 49 thrombocytopenia (< 100 × 10(9)/L) and 9 severe thrombocytopenia (< 30 × 10(9)/L). In the context of univariate logistic regression, severe thrombocytopenia demonstrated a significant association with increased APOs, encompassing preterm delivery before 34 weeks (OR, 8.74; 95%CI, 2.10-36.32, P = 0.0028), uteroplacental insufficiency (OR, 16.28; 95%CI, 1.99-133.53, P = 0.0093), preterm labor before 37 weeks (OR, 15.98; 95%CI, 3.16-80.80, P = 0.0008), and SGA (OR, 7.45; 95%CI, 1.87-29.73, P = 0.0045). A nonlinear relationship between the number of platelets and APOs was observed. The risk of APOs rose as platelet count decreased to a turning point (50 × 10(9)/L) (P < 0.05). Beyond a platelet count of 50 × 10(9)/L, no significant association was observed between platelet count and APO risk in OAPS patients. CONCLUSION: The risk of adverse pregnancy outcomes in patients with OAPS is contingent upon the severity of thrombocytopenia. Maintaining platelet counts above 50 × 10(9)/L is pivotal in mitigating this risk. The effective OAPS treatments may improve pregnancy outcomes.