Abstract
BACKGROUND: The purpose of this study was to provide a case report of a patient with uveitis-glaucoma-hyphema-vitreous hemorrhage (UGH plus) syndrome with intraocular lens (IOL) scleral fixation who presented with recurrent decreased vision and to discuss potential risk factors and treatment options. CASE PRESENTATION: A 54-year-old man with a history of multiple ocular traumas and surgeries underwent IOL reposition surgery (scleral fixation) in his right eye in July 2020. He complained of having blurred vision after rubbing his right eye in February 2023. We diagnosed him with UGH plus syndrome on the basis of successive anterior chamber inflammation, elevated intraocular pressure (IOP), hyphema and vitreous hemorrhage. Ultrasound biomicroscopy revealed a concave iris. Laser peripheral iridotomy (LPI) effectively controls UGH plus syndrome. CONCLUSIONS: We reported the successful management of UGH plus syndrome with a scleral-fixed IOL via the LPI. Given the increasing prevalence of IOL implantation, great importance should be attached to the possibility of UGH syndrome, especially in patients with high-risk factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-026-04720-0.