Utility of peripheral blood testing for detection and surveillance of clonal hematopoiesis in predisposed individuals

外周血检测在易感人群克隆性造血的检测和监测中的应用

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作者：Attardi,Enrico,Gray,Nathan,Lewis,Sara,Boals,Michelle,Shaker,Passant,Kotmayer,Lili,Sahoo,Sushree S,Li,Peng,Andersen,Erica F,Zhao,Jian,Pizzo,Lucilla,Oved,Joseph H,Jesudas,Rohith,Reiss,Ulrike M,Sharma,Richa,Christakopoulos,Georgios E,Bhoopalan,Senthil Velan,Takemoto,Clifford M,Kennedy,Alyssa,Voso,Maria Teresa,Kang,Guolian,Wlodarski,Marcin W
期刊：Blood影响因子：23.100
时间：2026起止号：2026 Feb 19;147(8):897-901
doi：10.1182/blood.2024028042

Abstract

In this study, 108 pediatric patients with bone marrow (BM) failure and leukemia predisposition were evaluated for presence of clonal hematopoiesis in peripheral blood (PB) and BM. Robust PB-BM concordance for mutations but decreased sensitivity in PB for chromosomal abnormalities was found.

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