Abstract
BACKGROUND: The maternal mortality ratio (MMR) is a core indicator of health-system performance and equity. In China, interpretation of recent maternal mortality trends is increasingly influenced by differences between modeled global estimates and national surveillance data. We aimed to characterize the maternal mortality transition and subnational inequities in China from 1990 to 2023 by comparing Global Burden of Disease (GBD) 2023 estimates with data from the National Maternal Mortality Surveillance System (NMMSS). METHODS: We integrated model-based estimates from the GBD 2023 with real-world data from China's NMMSS. Assessment focused on key burden metrics, including disability-adjusted life years, MMR, mortality and incidence. Joinpoint regression was used to identify temporal trend changes. Scenario-based projections and Bayesian age-period-cohort (BAPC) models were applied to forecast progress toward the "Healthy China 2030 target". Subnational inequalities in maternal healthcare service coverage were also examined. RESULTS: GBD estimates showed China's MMR declined from 121.9 (1990) to 10.7 (2023) per 100,000 live births, while NMMSS reported 15.1 per 100,000 live births in 2023. According to GBD, the leading cause shifted from maternal hemorrhage to indirect disorders, whereas NMMSS consistently identified obstetric hemorrhage as the primary cause. The urban-rural disparity narrowed substantially, but subnational inequities persisted, particularly in western provinces. The MMR rapid decline during 2004-2015 was followed by a plateau. Scenario-based projections indicate that sustaining recent progress would enable China to achieve the Healthy China 2030 target (MMR <12 per 100,000 live births). CONCLUSION: China has made remarkable progress in maternal health and significantly reduced urban-rural disparities. However, critical differences between GBD estimates and NMMSS data underscore the need for improved local data collection. Targeted strategies, such as integrating cardiovascular risk screening in eastern provinces and strengthening obstetric emergency capacity in western regions, are essential to further reduce maternal mortality and achieve the Healthy China 2030 goal.