A new hydrated crystalline form of N-[(E)-(4-hy-droxy-phen-yl)methyl-idene]-1H-1,2,4-triazol-3-amine and its anti-fungal activity

N-[(E)-(4-羟基苯基)亚甲基]-1H-1,2,4-三唑-3-胺的一种新型水合晶体及其抗真菌活性

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Abstract

The synthesis, crystal structure, Hirshfeld analysis, and anti-fungal assessment of a new monohydrated Schiff base with a triazole moiety are reported. The structural study revealed the presence of three significant hydrogen bonds (N-H⋯N, O-H⋯N, and O-H⋯O), which contribute to the cohesion of the crystal. These bonds generate two-dimensional layers parallel to the bc plane, built on the basis of rings with the graph-set motifs R (4) (4)(8) and R (4) (4)(24). The crystal structure is further consolidated by π-π inter-actions between similar rings. The anti-fungal activity of the Schiff base was evaluated against three fungi: Fusarium oxysporum, Botrytis cinerea, and Alternaria alternata, showing significant anti-fungal activity, particularly against Alternaria alternata.

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