Adapting Bower's intramolecular aziridination reaction allows for a metal-free synthesis of N-H aziridines

改进鲍尔的分子内氮丙啶化反应,可以实现无金属催化合成NH氮丙啶。

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Abstract

Inspired by Bower's intramolecular aziridination reaction, we have developed an intermolecular protocol for the preparation of N-H aziridines from olefins. Our reaction is operationally simple and involves stirring substrate with commercial N-Boc-O-tosylhydroxylamine and trifluoroacetic acid in 2,2,2-trifluoroethanol. The reaction is stereospecific, scalable, and does not utilize expensive transition metals. The substrate scope is broad, and the functional group tolerance is impressive.

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