Abstract
Concurrent chemoradiotherapy (CCRT) is a common treatment for advanced cervical cancer, and angiosarcoma rarely occurs at the irradiated site. We report a case of angiosarcoma diagnosed via a transvaginal ultrasound-guided needle biopsy of a mass in the rectovaginal space, which developed five years after CCRT in a patient with stage IIIB cervical cancer. The biopsy specimen was analyzed using next-generation sequencing (NGS), which identified relevant somatic genetic mutations. This case highlights the value of needle biopsy as a useful diagnostic tool and its potential role in guiding treatment decisions.