Abstract
Subphrenic abscesses are rare, yet clinically significant, and are often associated with intra-abdominal infections. The present case report describes the case of a 77-year-old male patient with an unusual presentation of a subphrenic abscess caused by Proteus mirabilis without typical predisposing factors. The patient experienced a prolonged 2-year course characterized by recurrent febrile episodes and respiratory symptoms. The diagnosis was confirmed through imaging and microbiological culture, with percutaneous drainage and culture-directed antibiotic therapy, including meropenem, leading to successful treatment. The multidrug-resistant nature of the pathogen, coupled with the atypical presentation of the patient, posed significant challenges in both diagnosis and management. The case described herein underscores the importance of comprehensive diagnostic imaging, timely intervention and individualized treatment strategies in managing such complex infections.