Abstract
INTRODUCTION: This study emphasizes the efficacy of triphala as a therapeutic agent over inflammatory condition in hydrogen sulfide (H(2) S) mediated inflammatory path in the presence of titanium (Ti) discs. MATERIALS AND METHOD: In the presence of triphala extracts, lipopolysaccharidetreated macrophages showed reduction in production of inflammatory mediators and intercellular free radicals (ROS) and downregulation of mRNA in TNF. RESULTS: Thus in the presence of propargylglycine, reduction of TNFα by triphala in the H(2) S inhibited group showed that the mechanism of action of triphala can be through the H(2) S pathway.