Abstract
Neurofibroma (NF) is a benign peripheral nerve sheath tumor which consists of Schwann cells, perineurial-like cells, and fibroblasts. The NF can be central or peripheral, alone or multiple which is a manifestation of Type I neurofibromatosis. NFs are mostly found in the tongue, oral mucosa, and lips when appearing in the mouth cavity, but they are rare at palate in a solitary form. We report a case of a solitary NF originating in the hard palate in a 30-year-old woman. The patient had an asymptomatic, nonulcerated, sessile, pink, and smooth nodule measuring 15 × 25 × 5 mm with a firm consistency and defined border on the left side of the posterior part of the hard palate. She had a similar history about 12 years ago which was diagnosed as a benign myxoid tumor which was excised that time. The lesion was excised with a 3-mm safe margin. The periosteum was excised, but the palatal bone was intact and was not excised. IHC was positive for S-100 immunostaining. Eventually, the mass was diagnosed as a NF. The important point is that following the patient with NF is necessary, because it could be the primary sign of Type I neurofibromatosis. The follow-up of this patient is continuing, and until the accomplishment of this report, no relapse was evident.