Abstract
Kaempferol liposome hydrogel is a novel drug carrier designed to solve the problems of the poor water solubility and low bioavailability of kaempferol. By combining kaempferol with liposomes and further forming a hydrogel, this composite formulation not only improves the stability of the drug but also enhances its penetration and therapeutic effect on the skin. It was demonstrated that the liposomal hydrogel of kaempferol had ex vivo and in vivo antioxidant activities, which could effectively inhibit the inflammatory response and oxidative stress and, thus, showed significant efficacy in the treatment of acute eczema. In the acute eczema model, kaempferol liposome hydrogel significantly improved the skin condition of mice by reducing the symptoms of skin redness, swelling, and itching. The experimental results showed that the hydrogel was rapidly absorbed into the skin after application and continued to release the drug to maintain its efficacy for a longer period of time. In addition, the kaempferol liposome hydrogel also showed good physicochemical stability and was not easily discolored or separated, making it suitable for long-term use. As an innovative drug carrier for the treatment of acute eczema, the kaempferol liposome hydrogel shows good application prospects and provides a new treatment option for eczema patients.