Abstract
Patients with a history of drug abuse and right-sided endocarditis are particularly susceptible to developing septic pulmonary emboli. Rarely, septic pulmonary emboli can cause severe lung injury resulting in parenchymal loss despite appropriate antibiotic therapy. We present 2 cases of severe lung injury associated with septic pulmonary emboli stemming from right-sided infective endocarditis, emphasizing 2 rare complications: bilateral spontaneous pneumothorax and pneumatocele formation.