Abstract
BACKGROUND: Research on Chronic Obstructive Pulmonary Disease (COPD) in the Intensive Care Unit (ICU) has expanded rapidly, yet a comprehensive, longitudinal bibliometric analysis mapping its is scientific evolution lacking. METHODS: We conducted a bibliometric analysis of 2,512 publications from the Web of Science Core Collection (2000-2025). A preliminary literature search confirmed no prior bibliometric study has specifically and systematically mapped this entire domain. Using VOSviewer and CiteSpace, we analyzed publication trends, collaborations, co-citation networks, and keyword bursts. RESULTS: Annual publications show a consistent upward trajectory, with accelerated growth post-2019. The United States, China, and France are leading contributors, with robust international collaboration. The intellectual structure has evolved from foundational mechanical ventilation research to integrated management and prognostic modeling. Current research frontiers emphasize non-invasive ventilation, acute exacerbation management, and outcomes in multi-organ failure. CONCLUSION: This study provides the first quarter-century roadmap of ICU-focused COPD research, demonstrating its maturation toward data-driven and personalized care. By delineating the thematic evolution and identifying emergent interdisciplinary frontiers, such as data science integration and post-ICU recovery, this analysis offers a strategic guide for prioritizing research and optimizing care for this vulnerable population.