Abstract
Eosinophilic pustular folliculitis (EPF) is a rare inflammatory dermatosis that predominantly affects seborrheic areas. The condition's pathogenesis is linked to T helper 2-driven eosinophilic inflammation. We presented a man with EPF involving the face, palms and soles, successfully treated by apremilast, a phosphodiesterase-4 inhibitor. Apremilast's efficacy in this case adds to emerging evidence supporting its use in EPF, particularly when traditional treatments fail.