Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis
利用脂肪酶催化 Domino Thia-Michael-Henry 动态共价体系拆分不对称合成取代硫杂环戊烷
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作者：Yan Zhang, Pornrapee Vongvilai, Morakot Sakulsombat, Andreas Fischer, Olof Ramström
Abstract
Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.
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