Abstract
PREMISE: Plants are frequently exposed to combinations of abiotic and biotic stresses that pose a greater threat to yield and productivity than individual stresses. However, knowledge of the impact of many stress combinations in numerous plants is limited due to the lack of experimental data, which could take decades to generate. To overcome this limitation, we utilized existing literature data from various plant species and stress combinations to derive biological inferences, thereby gaining a comprehensive understanding of plant responses through a computational tool. METHODS: Public databases were used to gather literature on the impact of various abiotic and biotic stress combinations. Then, a composite artificial neural network (ANN)-based multi-target classification and regression deep learning model was developed using machine learning algorithms. RESULTS: The model predicted the impact of stress interactions in plants, including the morphological parameters affected and percentage changes in those parameters, with an overall accuracy of 76.33%. Predicted reductions in yield were validated in rice under combined drought and heat stress. DISCUSSION: The ANN-based model developed in this study is a valuable resource for plant researchers seeking to understand the impact of stress combinations. The tool can make use of multivariate and complex combined stress datasets.