Abstract
OBJECTIVE: To describe the clinical presentation, surgical management, and reconstruction of maxillary odontogenic myxomas through two case reports, and to propose a comprehensive management algorithm to guide diagnosis and treatment decisions. CASE PRESENTATION: This study reports two cases treated at Piñero Hospital with resection and reconstruction using temporalis muscle flaps. Diagnosis was confirmed by clinical, radiological, and histopathological examinations. The first case involved a 36-year-old female with a multilobulated osteolytic lesion in the upper jaw; follow-up at 27 months showed no recurrence. The second case, a 27-year-old male, presented a large, aggressive osteolytic lesion; 32-month follow-up demonstrated successful healing without relapse. CONCLUSION: Maxillary odontogenic myxomas require individualized, multidisciplinary management. The proposed algorithm, integrating tumor size, extension, surgical approaches, and reconstruction options, offers a practical decision-making tool to improve clinical outcomes.