Abstract
BACKGROUND AND AIMS: Gastric cancer is a global health concern with high morbidity and mortality. This systematic review evaluates the potential of plant extracts in the prevention of gastric cancer by analyzing their bioactive mechanisms. METHODS: A total of 62 studies-including in vitro, in vivo, and clinical trials-were analyzed, focusing on their antiproliferative, proapoptotic, antiangiogenic, and anti-inflammatory properties. RESULTS: Extracts such as Marsdenia tenacissima, Curcuma longa, and Rhus verniciflua showed significant promise. CONCLUSION: Despite these findings, issues surrounding bioavailability, dosing standardization, and long-term safety require further investigation before clinical translation.