AptheraTM Intraocular Lens in a Latino Population: A Case Series

Apthera™人工晶状体在拉丁裔人群中的应用:病例系列

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Abstract

This study aims to evaluate postoperative vision in Latino patients who underwent the first small-aperture, nontoric, extended depth of focus Intraocular lens implantation (Apthera(TM)) in a Latino population. We conducted a chart review of 49 patients who underwent Apthera(TM) intraocular lens implantation (Bausch and Lomb, Rochester, NY, USA) in a Latino population. Descriptive analyses and statistical analyses were done. A total of 49 patients underwent surgery. Of these, there were 18 males (37%) and 31 females (63%). Their ages ranged from 42 to 77 years (mean age = 56.5 years). For the uncorrected distance visual acuity (UDVA, LogMAR) in the Fellow eye (F Eye) and uncorrected near visual acuity (UNVA, LogMAR) in the Apthera™ Eye (Ap Eye), at baseline, the mean preoperative UDVA in the F Eye was 0.255 ± 0.298 LogMAR, with a mean UDVA of 0.068 ± 0.102 LogMAR at one month and 0.059 ± 0.089 LogMAR at six months. In the Ap Eye, the mean UNVA was 0.715 ± 0.372 LogMAR preoperatively, 0.149 ± 0.118 LogMAR at one month, and 0.116 ± 0.154 LogMAR at six months. Mixed-effects regression confirmed that Ap Eyes had significantly higher LogMAR values than F Eyes at both one month (Coef = 0.059, z = 2.09, p = 0.037) and six months (Coef = 0.087, z = 2.34, p = 0.019).  The mean preoperative spherical equivalent (SE) in the F Eye was +0.353 ± 2.727 D, -0.339 ± 1.852 D at one month, and -0.168 ± 0.541 D at six months. In the Ap Eye, the mean SE was +0.311 ± 2.630 D preoperatively, -1.085 ± 0.885 D at one month, and -1.060 ± 0.861 D at six months. Regression analyses confirmed significantly more myopic outcomes in Ap Eyes compared to F Eyes at both one month (Coef = -0.737, z = -3.07, p = 0.002) and six months (Coef = -0.91, z = -4.88, p < 0.001). In the F Eye, the mean astigmatism was -0.609 ± 0.517 D preoperatively, -0.643 ± 0.601 D at one month, and -0.526 ± 0.599 D at six months. In the Ap Eye, the mean astigmatism was -0.781 ± 0.592 D preoperatively, -0.989 ± 0.935 D at one month, and -0.920 ± 0.940 D at six months. Mixed-effects regression suggested a trend toward greater residual astigmatism in Ap Eyes at one month (Coef = -0.307, z = -1.91,p = 0.057) and six months (Coef = -0.35, z = -1.76, p = 0.078), though these did not reach statistical significance.  Our findings show significant improvement in UNVA in the Ap Eye, which is compatible with reports from the IC-8 Apthera(TM )IOL USFDA clinical study. Regression analyses confirmed significantly more myopic outcomes in Ap Eyes compared to F Eyes at both one month and six months, supporting refractive predictability. In the F Eye, our results are within the expected postoperative goal. Astigmatic errors, however, did not improve in either eye. In conclusion, this surgery benefits both the F Eye and the Ap Eye in Latino patients.

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