Abstract
Pleomorphic adenoma (PA), the most common salivary gland tumor, presents unique challenges due to its diverse clinicopathologic features. The objective of this case series is to highlight the implication of detailed histopathological examination to guide appropriate diagnosis. This study reviews 10 cases of PA diagnosed at B.P. Koirala Institute of Health Sciences, Nepal, between 2011 and 2023. Patients ranged from 16 to 71 years, with a male-to-female ratio of 1:2.3. Most lesions (eight cases) were located on the palate, with additional cases, one on the upper lip and one on the cheek mucosa. Lesion sizes ranged from 1 to 3 cm(2) and durations from 2 months to 4 years. Clinically, all lesions were well encapsulated, nontender, and nonulcerated and had normal overlying mucosa. Histopathologically, cases included classical PA, myxoid, and cellular types. Common findings were ductal structures filled with eosinophilic material, a "swarm bee" appearance, plasmacytoid cells, and myxoid stroma. Squamous differentiation and psammoma bodies were observed in some cases. No osseous or cartilaginous components were detected. All cases were excised, with no recurrences reported during at least 2 years of follow-up. Hence, proper diagnosis is crucial for effective management and long-term outcomes of PA.